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pentobarbital will lower the level or impact of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with powerful CYP3A4 inducers; these drugs lessen exposure to